p53 Family Isoforms
نویسندگان
چکیده
منابع مشابه
p53 Family: Role of Protein Isoforms in Human Cancer
TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to...
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Although p53 defines cellular responses to cancer treatment it is not clear how p53 can be used to control cell fate outcome. Data demonstrate that so-called p53 does not exist as a single protein, but is in fact a group of p53 protein isoforms whose expression can be manipulated to control the cellular response to treatment.
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The p53 family network is a unique cellular processor that integrates information from various pathways and determines cellular choices between proliferation, replication arrest/repair, differentiation, senescence, or apoptosis. The most studied role of the p53 family is the regulation of stress response and tumor suppression. By removing damaged cells from the proliferating pool, p53 family me...
متن کاملThe p53/p63/p73 family
The p53 gene is a tumor suppressor gene and the most frequent site of genetic alterations found in human cancers (Hollstein et al., 1991, 1996). Transgenic mice expressing mutant p53 or p53−/− mice are very prone to both spontaneous and induced tumors (Donehower et al., 1992). The p53 protein is a sequencespecific transcription factor that regulates the expression of genes involved in cell cycl...
متن کاملThe emerging p53 gene family.
Perturbation of p53 protein function is a common, if not universal, finding in human cancer. Tumor suppression by p53 is due, at least in part, to its ability to activate transcription of certain genes involved in cell cycle control and apoptosis (programmed cell death). Two additional members of the mammalian p53 family, p73 and p51, which is also known as p40, p63, KET, or p73L, were recently...
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ژورنال
عنوان ژورنال: Current Pharmaceutical Biotechnology
سال: 2007
ISSN: 1389-2010
DOI: 10.2174/138920107783018444